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KMID : 0361020210640080540
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Korean Journal of Otolaryngology - Head and Neck Surgery
2021 Volume.64 No. 8 p.540 ~ p.547
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A Comparative Study on the Treatment Effect of Lipo-Prostagladin with Hypertension and Diabetes Mellitus in Sudden Sensorineural Hearing Loss Patients
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Heo Hye-Jeong
Choi Chul-Hee
Kim Myung-Gu
Hong Sung-Hwa
Seo Ji-Won
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Abstract
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Background and Objectives Several drugs which can improve blood flow have been usedas treatment options for sudden sensorineural hearing loss (SSNHL) based on the theory thatimprovement of perfusion into the inner ear will help restore hearing. Lipo-prostaglandin E1(lipo-PGE1) is a well-known vasodilator that increases peripheral blood flow. The purpose ofthis study was to investigate the effect of lipo-PGE1 on the recovery of the SSNHL patientswith hypertension or diabetes.
Subjects and Method We retrospectively analyzed 801 patients who were diagnosed withSSNHL from January 2007 to December 2018. All patients were treated with 48 mg of methylprednisolonefor 5 days; some patients received lipo-PGE1, depending on the attending physician.
They were divided into four groups according to the presence or absence of hypertensionand diabetes. Hearing test was performed again one month after treatment and comparedwith the test results at the time of diagnosis.
Results As a result of comparing the hearing thresholds before and after the treatment ineach group, there was a significant improvement in hearing thresholds in all groups (p<0.001).
However, when comparing the effect of lipo-PGE1 for hearing change, there was a significantdifference only in the group without any underlying diseases (p=0.016).
Conclusion In this study, we show that lipo-PGE1 was helpful in hearing recovery whenused in patients without underlying diseases rather than patients with hypertension or diabetes.
Further studies will be needed to determine the therapeutic effects of lipo-PGE1 as an adjuvanttreatment in SSNHL patients.
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KEYWORD
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Diabetes mellitus, Hypertension, Lipo-PGE1, Sudden hearing loss
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